A wet-lab postdoctoral position is available immediately in the Northcott Lab (Department of Developmental Neurobiology) to join a highly collaborative team studying the developmental and molecular basis of the childhood brain tumor medulloblastoma. The Northcott Lab has established an internationally renowned track record in pediatric neuro-oncology, substantiated by numerous impactful publications in Nature, Cancer Cell, Nature Cancer, Lancet Oncology, and Journal of Clinical Oncology. Leveraging our exquisite access to patient material linked to large clinical trial cohorts, we are applying …

The dos Santos Laboratory is seeking highly motivated postdoctoral fellows to join a dynamic and collaborative research program focused on defining epigenetic and non-genetic determinants of breast homeostasis and cancer risk. Project Description: Our research uniquely centers on normal breast biology as a foundation for cancer prevention, integrating advanced mouse models, organoid systems, lineage tracing, and single-cell genomics to uncover how physiological life events reprogram mammary tissue and influence tumor initiation and therapeutic response. Our previous work has uncovered key …

A Postdoctoral Research Associate position is available in the laboratory of Dr. Yuuta Imoto in the Department of Developmental Neurobiology at St. Jude Children’s Research Hospital. The Imoto lab uses super-resolution microscopy and electron-microscopy to investigate rapid synaptic organelle dynamics during neurotransmission. The Fellow will design and conduct experiments aimed at identifying molecular mechanisms by which endocytic structures remove damaged proteins in human physiology and neurodegenerative disorders. Successful candidates will have: A PhD in cell biology, neuroscience, or related discipline …

A postdoctoral position is available at St. Jude Children’s Research Hospital for an outstanding and highly motivated candidate to investigate the cellular signaling in the innate immune system during infections, inflammatory diseases, and cancers. Project Description St. Jude Children’s Research Hospital is committed to the education and training of the next generation of research scientists. St. Jude trainees are able to learn from clinical and basic science investigators who work in close proximity and interact regularly to translate scientific discoveries …

The Yang Lab in Department of Surgery at St. Jude Children’s Research Hospital is seeking a highly motivated Postdoctoral Fellow to join our translational research team. Project Description The research focuses on understanding the novel functions of fusion transcriptional factors in rhabdomyosarcoma. This work is highly mechanistic and translational, leveraging cutting-edge genetic, epigenetic, cellular and pharmacologic tools to inform better therapies using human and genetic models. Key Responsibilities Design and conduct experiments investigating the mechanism of chimeric transcriptional factors in …

A postdoctoral research associate position is open in Dr. Yadav Sapkota’s lab in Epidemiology & Cancer Control. Project DescriptionWe are seeking a highly motivated Postdoctoral Research Fellow to join the laboratory of Dr. Yadav Sapkota in the Department of Epidemiology and Cancer Control at St. Jude Children’s Research Hospital. Successful candidates will work on projects related to pharmacogenomics of long-term toxicities of cancer therapy in childhood cancer survivors. Specific research topics include 1) genetic association analyses (whole genome and whole …

A postdoctoral position is available in the laboratory of Samuel W. Brady. The lab focuses on identifying and therapeutically targeting key dependencies in pediatric solid tumors (Banu et al., Science Advances 12:eaeb3503 (2026) http://www.science.org/doi/10.1126/sciadv.aeb3503 and cancer genomics, including mutational signatures (Brady et al., Cancer Discovery 2026 http://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-25-0231/783733/Therapy-related-mutational-signatures-in. Project Description: This position involves the experimental study of key pediatric cancer dependencies, and the identification of new approaches to target them therapeutically. This includes studies of protein signaling, subcellular relocalization, pharmacological studies …

We are excited to announce a postdoctoral fellowship in the laboratory of Dr. Lillian Guenther, an Assistant Member in the Division of Molecular Oncology at St. Jude Children’s Research Hospital in Memphis, TN. Project Description: Dr. Guenther’s research specifically focuses on identification and investigation into the biology of novel therapeutic targets in pediatric bone sarcomas. Dr. Guenther’s research utilizes genome-scale CRISPR screening and other complementary large-scale chemical and genomic screening modalities, as well as advanced molecular biology and biochemical techniques …

A fully funded postdoctoral position is immediately available Mark Hatley’s laboratory in the Molecular Oncology Division of the Department of Oncology at St. Jude Children’s Hospital. Project Description The Hatley lab studies how normal development processes are perturbed to drive pediatric embryonal tumors using rhabdomyosarcoma as a model system. Our findings defined the cell of origin of rhabdomyosarcoma, a presumed skeletal muscle tumor, as an endothelial progenitor cell (Cancer Cell, 33:108-124, 2018 and Nature Communications, 14:729, 2023). We now seek …